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Dear Pharmacist Miracle mushroom: Lentanin in shiitake protects you from cancer

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Posted: Friday, February 22, 2013 7:48 am

Dear Pharmacist: I’m not a fan of fungus, but I’ve heard that shiitake mushrooms are good for cancer. What do you think? — C.E., Boston

Answer: I think some mushrooms are amazing! Shiitake, known botanically as Lentinula edodes, are seriously great for immune function. They’re not just a Japanese delicacy; these mushrooms have been used for centuries, and have a safe history of healing that goes back thousands of years. Chinese medicine traditionally uses mushrooms to enhance qi (pronoucned “chee,” which refers to your vital life force). We are not talking portabello, though, this is altogether different.

Shiitake extracts definitely support immune function, but they also appear to have antiviral (even influenza), antibacterial; and antifungal effects. Ironic that fungus fights fungus, but it’s basically the good fungus (shiitake) killing the pathogenic ones. The 2009 study published in Complimentary Therapies in Clinical Practice had data to show that  shiitake had “extensive antimicrobial activity against 85 percent of the organisms it was tested on, including 50 percent of the yeast and mould species in the trial.” This study even compared it to ciprofloxacin, a popular antibiotic. I found a trial suggesting antiviral effects against HIV virus as well as proliferation of leukemia! The activity was due to “lentin,” an antifungal compound found in shiitake. Is the study tight enough for you to go off your current treatment? No way, but it’s worth including in your regimen, with your doctor’s blessings.

Researchers isolated a substance called “lentinan” in shiitake that sparks your own immune system to do a better job at getting rid of cancer cells. Researchers conclude that lentinan helps “prolong the survival of patients with advanced gastric cancer.” In another Japanese study, published in Cancer & Chemotherapy, July 2012, researchers looking at shiitake’s effects on liver cancer suggested that the mushrooms “might be used for alleviating side effects of chemotherapy and preventing the progression of liver cancer for patients with chronic hepatitis.”  

Shiitake is active against the hepatitis B virus, so you might say this is a liver-loving mushroom in many ways. It protects the colon, too. Over 10 years ago, a study published in the Journal of Alternative and Complementary Medicine found that lentinan was “able to retard the development of tumors” in mice.  In fact, they said, “significant regression in tumor formation was observed.” Remarkable!

Many studies have found that shiitake mushrooms are helpful for everyday ailments. For example, some research shows that shiitake may reduce cholesterol levels in the blood and lower blood pressure. Did I mention that shiitake mushrooms are a natural source of protein and vitamin D? Both  are important for immunity.

Shiitake mushrooms taste good. I add them to my jasmine rice along with pure saffron, turmeric, onions, grapeseed oil and garlic. Yum!  There are excellent supplements/extracts of shiitake sold at health food stores, and you can also buy multi-tasking formulas which contain several different medicinal mushrooms. Those are a little harder to find; two good ones are MycoPhyto by Econugenics or Mushroom Optimizer by Jarrow.

This information is not intended to diagnose, treat, cure or prevent any disease. For more information about Suzy Cohen, visit her website at



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